KHDRBS2

Across TCGA patient cohorts, KHDRBS2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDRBS2-associated genes across cancer lineages are 4E-BP1, 14-3-3_beta, and eEF2. Each is linked with KHDRBS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KHDRBS2-to-partner and partner-to-KHDRBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KHDRBS2-low versus KHDRBS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDRBS2→partner) and Y-score (partner→KHDRBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.378	+2.999	<.001	<.001	3	3
COAD	14-3-3_beta →	-0.267	-3.144	.007	.019	3	2
UCEC	eEF2 →	+0.268	+3.321	.025	.009	3	2
UCEC	ACC1 →	+0.295	+3.335	.015	.005	3	2
UCEC	p53 →	-0.278	-2.459	.032	.018	3	2
UCEC	Shc_pY317 →	-0.177	-1.874	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

4E-BP1 by KHDRBS2 expression — UCEC

Explore this box plot interactively →