KHDRBS2

Across TCGA cell cohorts, KHDRBS2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KHDRBS2-associated genes across cancer lineages are AQP12A, NOBOX, and GIMAP7. Each is linked with KHDRBS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDRBS2-to-partner and partner-to-KHDRBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP12A grouped by KHDRBS2-low versus KHDRBS2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDRBS2→partner) and Y-score (partner→KHDRBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AQP12A →	+0.059	+4.108	<.001	.005	3	1
CNS	NOBOX →	+0.024	+4.321	<.001	.009	3	1
CNS	GIMAP7 →	+0.044	+4.169	<.001	.008	3	1
SKIN	OR2F1 →	+0.004	+3.099	<.001	.002	3	1
SKIN	PPIAL4E →	+0.040	+3.084	<.001	.002	3	1
BLOOD_Lymphoma	FTHL17 →	+0.180	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

AQP12A by KHDRBS2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →