KHDC4

Across TCGA pan-cancer cohorts, KHDC4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KHDC4 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KHDC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KHDC4 expression acts as an unfavorable survival marker.

SKCM, LUSC, and HNSC are the cancer types where KHDC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.138	0.841	<.001	12	view →
LUSC	OS	Median	All	0.138	0.818	.003	6	view →
HNSC	OS	Median	III,IV	0.159	0.627	.039	6	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KHDC4–SKCM (OS)

Open the SKCM breakdown →