KHDC4

Across TCGA pan-cancer cohorts, KHDC4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KHDC4 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KHDC4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KHDC4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where KHDC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.905	0.360	.003	20	view →
HNSC	OS	Tertile	All	0.840	0.959	.001	20	view →
LSCC	DFS	Median	All	0.945	0.431	.005	5	view →
UCEC	DFS	Median	All	1.000	0.936	.023	4	view →
PDAC	OS	Quartile	II,III,IV	0.297	0.589	.041	2	view →
CCRCC	DFS	Tertile	III,IV	0.820	0.440	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KHDC4–LUAD (OS)

Open the LUAD breakdown →