KHDC4

Across TCGA pan-cancer cohorts, KHDC4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of KHDC4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where KHDC4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KHDC4 is over-expressed in tumor.

LSCC, COAD, and HNSC are the cancer types where KHDC4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KHDC4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.308	<.001	8	view →
COAD	All	II,III,IV	+0.219	.002	8	view →
HNSC	Male	All	+0.209	<.001	8	view →
LUAD	Female	II,III,IV	+0.171	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

KHDC4–LSCC

Open the LSCC breakdown →