KHDC4

Across TCGA patient cohorts, KHDC4 mutation is significantly associated with the RNA expression of many other genes, with 1,990 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDC4-associated genes across cancer lineages are C9orf43, PSMC3IP, and USP30. Each is linked with KHDC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KHDC4-to-partner and partner-to-KHDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf43 grouped by KHDC4-low versus KHDC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC4→partner) and Y-score (partner→KHDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C9orf43 →	+0.395	+2.169	<.001	.003	3	3
UCEC	PSMC3IP →	+0.694	+2.930	<.001	<.001	3	3
UCEC	USP30 →	+0.378	+2.202	.003	.001	3	3
SKCM	SNRPCP20 →	+0.157	+3.347	<.001	.002	3	3
UCEC	DHX37 →	+0.450	+2.234	<.001	.001	3	2
UCEC	VPS26B →	+0.484	+3.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,990 associations by consensus.

C9orf43 by KHDC4 expression — UCEC

Explore this box plot interactively →