KHDC4

Across TCGA patient cohorts, KHDC4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDC4-associated genes across cancer lineages are 4E-BP1, PKC-delta_pS664, and ERK2. Each is linked with KHDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDC4-to-partner and partner-to-KHDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KHDC4-low versus KHDC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC4→partner) and Y-score (partner→KHDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.217	+2.199	.041	.033	3	2
BLCA	PKC-delta_pS664 →	-0.180	-2.999	.033	.035	3	1
UCEC	ERK2 →	+0.189	+2.999	.012	.035	3	1
UCEC	JNK2 →	+0.179	+1.763	.022	.048	3	1
UCEC	MSH2 →	-0.329	-3.558	<.001	.002	3	1
UCEC	Annexin_VII →	-0.124	-2.502	.023	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

4E-BP1 by KHDC4 expression — UCEC

Explore this box plot interactively →