KHDC4

Across TCGA cell cohorts, KHDC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,282 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KHDC4-associated GO terms across cancer lineages are Regulation of RNA splicing, Regulation of mRNA splicing, via spliceosome, and Regulation of mRNA processing. Each is linked with KHDC4 in more than 17 cancer types. Because this analysis shows association rather than direction, both KHDC4-to-partner and partner-to-KHDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by KHDC4-low versus KHDC4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC4→partner) and Y-score (partner→KHDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of RNA splicing →	+0.091	+1.227	.001	.001	3	18
STOMACH	Regulation of mRNA splicing, via spliceosome →	+0.099	+0.671	.002	.005	3	18
OVARY	Regulation of mRNA processing →	+0.096	+1.141	<.001	<.001	3	18
OESOPHAGUS	mRNA splice site recognition →	+0.190	+1.353	<.001	<.001	3	18
STOMACH	RNA catabolic process →	+0.087	+1.089	<.001	.001	3	18
STOMACH	Nuclear-transcribed mRNA catabolic process →	+0.102	+1.134	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,282 associations by consensus.

Regulation of RNA splicing by KHDC4 expression — BONE

Explore this box plot interactively →