KHDC4

Across TCGA cell cohorts, KHDC4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KHDC4-associated genes across cancer lineages are CFAP97D2, C4orf50, and TRIM77. Each is linked with KHDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDC4-to-partner and partner-to-KHDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFAP97D2 grouped by KHDC4-low versus KHDC4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC4→partner) and Y-score (partner→KHDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	DPRX →	+0.109	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CFAP97D2 by KHDC4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →