KHDC1L

Across TCGA pan-cancer cohorts, KHDC1L mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of KHDC1L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KHDC1L mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KHDC1L is over-expressed in tumor.

HNSC and LSCC are the cancer types where KHDC1L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KHDC1L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+1.107	.003	5	view →
LSCC	All	All	+0.642	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

KHDC1L–HNSC

Open the HNSC breakdown →