KHDC1L

Across TCGA cell cohorts, KHDC1L mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KHDC1L-associated genes across cancer lineages are TCF21, APOL5, and TACR3. Each is linked with KHDC1L in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDC1L-to-partner and partner-to-KHDC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by KHDC1L-low versus KHDC1L-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC1L→partner) and Y-score (partner→KHDC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.011	+4.705	<.001	.003	3	1
BLOOD_Leukemia	APOL5 →	+0.021	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	OR10V1 →	+0.035	+5.569	<.001	.001	3	1
BLOOD_Leukemia	HTR3D →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.060	+4.539	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TCF21 by KHDC1L expression — BLOOD_Leukemia

Explore this box plot interactively →