KHDC1

Across TCGA pan-cancer cohorts, KHDC1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KHDC1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KHDC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KHDC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where KHDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.356	0.922	.001	20	view →
LUAD	OS	Median	II,III,IV	0.838	0.269	.033	4	view →
LSCC	DFS	Median	All	0.888	0.206	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KHDC1–PDAC (OS)

Open the PDAC breakdown →