KHDC1

Across TCGA patient cohorts, KHDC1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KHDC1-associated genes across cancer lineages are eIF4G, EGFR_pY1068, and FoxM1. Each is linked with KHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDC1-to-partner and partner-to-KHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by KHDC1-low versus KHDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC1→partner) and Y-score (partner→KHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.284	+2.000	.026	.030	3	2
UCEC	EGFR_pY1068 →	-0.261	-2.321	.011	.006	3	1
UCEC	FoxM1 →	+0.247	+2.321	.021	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.148	-2.575	.004	.010	3	1
UCEC	ACC1 →	+0.376	+3.013	.012	.018	3	1
UCEC	HER3_pY1289 →	+0.079	+1.833	.026	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4G by KHDC1 expression — UCEC

Explore this box plot interactively →