KEAP1

Across TCGA pan-cancer cohorts, KEAP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KEAP1 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KEAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KEAP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and CCRCC are the cancer types where KEAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.869	.042	18	view →
LSCC	OS	Quartile	All	0.963	0.773	.007	8	view →
CCRCC	DFS	Tertile	All	0.924	0.712	.023	7	view →
PDAC	DFS	Tertile	All	0.505	0.297	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KEAP1–COAD (DFS)

Open the COAD breakdown →