KEAP1

Across TCGA patient cohorts, KEAP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,724 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KEAP1-associated proteins across cancer lineages are RAVER1, MEPCE, and SUGP1. Each is linked with KEAP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both KEAP1-to-partner and partner-to-KEAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KEAP1 versus RAVER1 in OV, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KEAP1→partner) and Y-score (partner→KEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAVER1 →	+0.435	+0.790	.001	.001	3	7
LSCC	MEPCE →	+0.339	+0.854	<.001	<.001	3	6
GBM	SUGP1 →	+0.306	+0.332	<.001	<.001	3	5
GBM	U2SURP →	+0.274	+0.270	<.001	.001	3	5
OV	KRI1 →	+0.470	+0.617	<.001	<.001	3	5
LSCC	RRBP1 →	-0.335	-0.649	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,724 associations by consensus.

KEAP1 vs RAVER1 — OV

Explore this scatter interactively →