KEAP1

Across TCGA patient cohorts, KEAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,926 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KEAP1-associated genes across cancer lineages are ILF3, MRPL4, and CDC37. Each is linked with KEAP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both KEAP1-to-partner and partner-to-KEAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KEAP1 versus ILF3 in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KEAP1→partner) and Y-score (partner→KEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ILF3 →	+0.534	+0.450	<.001	<.001	3	6
OV	MRPL4 →	+1.003	+0.523	<.001	<.001	3	6
OV	CDC37 →	+0.538	+0.436	<.001	<.001	3	6
OV	ECSIT →	+1.079	+0.522	<.001	.001	3	6
OV	ZNF562 →	+0.553	+0.440	.001	<.001	3	6
LSCC	ANP32B →	+0.700	+0.420	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,926 associations by consensus.

KEAP1 vs ILF3 — LSCC

Explore this scatter interactively →