KEAP1

Across TCGA patient cohorts, KEAP1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KEAP1-associated genes across cancer lineages are Cyclin-B1, FASN, and PRDX1. Each is linked with KEAP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both KEAP1-to-partner and partner-to-KEAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by KEAP1-low versus KEAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KEAP1→partner) and Y-score (partner→KEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.539	+1.765	.010	.014	3	5
LUAD	FASN →	+0.442	+1.415	<.001	<.001	3	3
LUSC	PRDX1 →	+0.357	+2.000	<.001	.008	3	3
LUAD	G6PD →	+0.890	+2.554	<.001	<.001	3	2
LUSC	HER2_pY1248 →	-0.201	-1.575	.019	.017	3	2
LUSC	JNK_pT183_Y185 →	-0.089	-1.575	.018	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Cyclin-B1 by KEAP1 expression — UCEC

Explore this box plot interactively →