KEAP1

Across TCGA cell cohorts, KEAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,261 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KEAP1-associated GO terms across cancer lineages are Regulation of glycolytic process through fructose-6-phosphate, Negative regulation of glycolytic process through fructose-6-phosphate, and Negative regulation of protein localization to chromatin. Each is linked with KEAP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both KEAP1-to-partner and partner-to-KEAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of glycolytic process through fructose-6-phosphate grouped by KEAP1-low versus KEAP1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KEAP1→partner) and Y-score (partner→KEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of glycolytic process through fructose-6-phosphate →	+0.140	+1.109	<.001	<.001	3	13
BREAST	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.140	+1.109	<.001	<.001	3	13
URINARY_TRACT	Negative regulation of protein localization to chromatin →	+0.141	+1.283	<.001	<.001	3	12
LUNG_SCLC	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.111	+0.642	.005	.001	3	11
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.124	+0.666	.005	<.001	3	11
BREAST	Chromosome condensation →	+0.123	+0.656	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,261 associations by consensus.

Regulation of glycolytic process through fructose-6-phosphate by KEAP1 expression — BREAST

Explore this box plot interactively →