KEAP1

Across TCGA cell cohorts, KEAP1 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KEAP1-associated genes across cancer lineages are ACTL9, TREML4, and PROP1. Each is linked with KEAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KEAP1-to-partner and partner-to-KEAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTL9 grouped by KEAP1-low versus KEAP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KEAP1→partner) and Y-score (partner→KEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACTL9 →	+0.401	+3.584	.003	.003	3	2
LUNG_SCLC	TREML4 →	+0.243	+3.491	.001	.008	3	2
LARGE_INTESTINE	PROP1 →	+0.027	+2.791	<.001	.005	3	2
LARGE_INTESTINE	MSH4 →	+0.331	+3.464	<.001	.004	2	3
BLOOD_Leukemia	C16orf92 →	+0.121	+2.774	<.001	.006	3	2
BLOOD_Leukemia	TSSK1B →	+0.010	+3.289	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

ACTL9 by KEAP1 expression — LUNG_SCLC

Explore this box plot interactively →