KDSR

Across TCGA patient cohorts, KDSR mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDSR-associated genes across cancer lineages are INPP4B, MEK1, and Myosin-IIa. Each is linked with KDSR in more than 1 cancer types. Because this analysis shows association rather than direction, both KDSR-to-partner and partner-to-KDSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by KDSR-low versus KDSR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDSR→partner) and Y-score (partner→KDSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.368	-2.999	.029	.035	3	1
UCEC	MEK1 →	+0.559	+3.321	.003	.010	3	1
UCEC	Myosin-IIa →	+0.208	+2.177	.032	.035	3	1
UCEC	Akt →	-0.244	-2.990	.041	.036	3	1
UCEC	EGFR_pY1068 →	-0.311	-3.321	.018	.010	2	1
UCEC	Shc_pY317 →	-0.289	-3.169	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

INPP4B by KDSR expression — UCEC

Explore this box plot interactively →