KDR

Across TCGA patient cohorts, KDR protein abundance is significantly associated with the RNA expression of many other genes, with 2,900 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KDR-associated genes across cancer lineages are LYVE1, HCN3, and PGAP2. Each is linked with KDR in more than 1 cancer types. Because this analysis shows association rather than direction, both KDR-to-partner and partner-to-KDR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KDR versus LYVE1 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDR→partner) and Y-score (partner→KDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LYVE1 →	+0.934	+0.502	<.001	.002	3	2
CCRCC	HCN3 →	-0.664	-0.723	<.001	<.001	3	2
LSCC	PGAP2 →	-0.470	-0.502	.005	.002	3	2
LSCC	CYSLTR1 →	+0.569	+0.519	.003	.002	3	2
CCRCC	IHO1 →	+0.867	+0.719	<.001	.002	3	2
LSCC	OGFRP1 →	-0.696	-0.502	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,900 associations by consensus.

KDR vs LYVE1 — LSCC

Explore this scatter interactively →