KDR

Across TCGA patient cohorts, KDR mutation is significantly associated with the RNA expression of many other genes, with 6,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDR-associated genes across cancer lineages are SLC19A3, ACKR3, and ENO1. Each is linked with KDR in more than 3 cancer types. Because this analysis shows association rather than direction, both KDR-to-partner and partner-to-KDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC19A3 grouped by KDR-low versus KDR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDR→partner) and Y-score (partner→KDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC19A3 →	-1.181	-2.886	<.001	.001	3	4
UCEC	ACKR3 →	-0.504	-2.070	.004	<.001	3	4
COAD	ENO1 →	+0.580	+2.740	<.001	.002	3	4
COAD	FMO4 →	-0.628	-3.876	<.001	<.001	3	4
LAML	OR12D1 →	+0.083	+5.135	<.001	.007	3	3
COAD	RUBCNL →	-1.386	-2.415	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,435 associations by consensus.

SLC19A3 by KDR expression — COAD

Explore this box plot interactively →