KDR

Across TCGA patient cohorts, KDR mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDR-associated genes across cancer lineages are CD20, INPP4B, and mTOR_pS2448. Each is linked with KDR in more than 2 cancer types. Because this analysis shows association rather than direction, both KDR-to-partner and partner-to-KDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD20 grouped by KDR-low versus KDR-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDR→partner) and Y-score (partner→KDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD20 →	+0.223	+2.700	<.001	.005	3	3
UCEC	INPP4B →	-0.181	-1.807	.042	.003	3	3
UCEC	mTOR_pS2448 →	-0.120	-1.986	.003	.002	3	3
UCEC	PCNA →	+0.198	+1.540	<.001	.001	3	3
UCEC	CD49b →	-0.230	-1.906	.003	.004	3	3
UCEC	4E-BP1 →	+0.284	+4.087	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

CD20 by KDR expression — LUAD

Explore this box plot interactively →