KDR

Across TCGA cell cohorts, KDR mutation is significantly associated with the RNA expression of many other genes, with 1,041 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDR-associated genes across cancer lineages are MPC1L, PATE3, and TBC1D28. Each is linked with KDR in more than 2 cancer types. Because this analysis shows association rather than direction, both KDR-to-partner and partner-to-KDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPC1L grouped by KDR-low versus KDR-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDR→partner) and Y-score (partner→KDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MPC1L →	+0.062	+4.087	<.001	.009	3	3
SOFT_TISSUE	PATE3 →	+0.032	+4.635	.002	.003	3	2
BLOOD_Leukemia	TBC1D28 →	+0.076	+2.926	<.001	.009	3	2
BLOOD_Leukemia	LRIT2 →	+0.093	+4.684	<.001	<.001	3	2
LUNG_SCLC	INSL4 →	+0.022	+3.058	.002	.004	3	2
BLOOD_Lymphoma	PIWIL3 →	+0.116	+4.191	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,041 associations by consensus.

MPC1L by KDR expression — URINARY_TRACT

Explore this box plot interactively →