KDM7A

Across TCGA patient cohorts, KDM7A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM7A-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Caspase-7-cleavedD198, and p62 Lck ligand. Each is linked with KDM7A in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM7A-to-partner and partner-to-KDM7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by KDM7A-low versus KDM7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM7A→partner) and Y-score (partner→KDM7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.422	-1.794	.023	.027	3	3
UCEC	Caspase-7-cleavedD198 →	+0.933	+2.720	<.001	.003	3	2
UCEC	p62 Lck ligand →	+0.405	+3.710	.002	<.001	3	2
UCEC	Rad50 →	-0.224	-3.000	.025	.001	3	2
UCEC	Rictor_pT1135 →	-0.094	-1.807	.025	.027	3	2
LUSC	p38-MAPK →	+0.150	+2.179	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

p38-MAPK_pT180_Y182 by KDM7A expression — UCEC

Explore this box plot interactively →