KDM6A

Across TCGA pan-cancer cohorts, KDM6A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KDM6A data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KDM6A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KDM6A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where KDM6A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	1.000	0.270	.008	44	view →
CCRCC	DFS	Quartile	All	0.519	0.909	<.001	24	view →
PDAC	DFS	Quartile	III,IV	0.440	0.810	.003	14	view →
LUAD	OS	Median	All	0.999	0.923	.016	10	view →
LSCC	OS	Quartile	All	1.000	0.738	.002	10	view →
GBM	OS	Median	All	0.947	0.786	.037	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KDM6A–UCEC (DFS)

Open the UCEC breakdown →