KDM6A

Across TCGA cell cohorts, KDM6A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,738 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KDM6A-associated GO terms across cancer lineages are Regulation of heterochromatin formation, Regulation of chromatin organization, and Growth hormone secretion. Each is linked with KDM6A in more than 14 cancer types. Because this analysis shows association rather than direction, both KDM6A-to-partner and partner-to-KDM6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heterochromatin formation grouped by KDM6A-low versus KDM6A-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM6A→partner) and Y-score (partner→KDM6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of heterochromatin formation →	+0.086	+0.855	.008	.001	2	15
BLOOD_Leukemia	Regulation of chromatin organization →	+0.089	+0.961	<.001	<.001	3	12
BONE	Growth hormone secretion →	+0.138	+1.177	<.001	<.001	3	12
LARGE_INTESTINE	Heterochromatin formation →	+0.052	+0.890	.002	.001	3	12
STOMACH	Post-transcriptional gene silencing →	+0.098	+0.893	<.001	.003	3	11
LARGE_INTESTINE	Regulation of RNA export from nucleus →	+0.105	+1.167	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,738 associations by consensus.

Regulation of heterochromatin formation by KDM6A expression — KIDNEY

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