KDM6A

Across TCGA cell cohorts, KDM6A mutation is significantly associated with the RNA expression of many other genes, with 408 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM6A-associated genes across cancer lineages are PRR30, SUN2, and CCNB1IP1. Each is linked with KDM6A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM6A-to-partner and partner-to-KDM6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by KDM6A-low versus KDM6A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM6A→partner) and Y-score (partner→KDM6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRR30 →	+0.010	+4.029	.003	.009	3	2
URINARY_TRACT	SUN2 →	+0.765	+2.459	.005	.004	3	1
URINARY_TRACT	CCNB1IP1 →	-0.655	-3.424	.002	<.001	3	1
URINARY_TRACT	PGK1 →	+0.725	+2.459	.003	.004	3	1
URINARY_TRACT	RPN2 →	+0.595	+3.169	<.001	.002	3	1
URINARY_TRACT	SERINC3 →	+0.616	+3.129	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 408 associations by consensus.

PRR30 by KDM6A expression — OVARY

Explore this box plot interactively →