KDM5D

Across TCGA pan-cancer cohorts, KDM5D RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KDM5D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KDM5D RNA is repressed in tumor relative to normal tissue. In most cancer types KDM5D is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and CHOL are the cancer types where KDM5D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM5D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−1.899	<.001	6	view →
KICH	Male	III,IV	−2.232	.004	4	view →
CHOL	All	II,III,IV	+2.054	.028	3	view →
HNSC	Male	II,III,IV	−0.912	.005	2	view →
STAD	Male	All	−0.897	.003	2	view →
LUSC	Male	All	−0.771	<.001	2	view →
KIRC	Male	All	−0.417	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

KDM5D–KIRP

Open the KIRP breakdown →