KDM5C

Across TCGA pan-cancer cohorts, KDM5C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KDM5C data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KDM5C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KDM5C expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where KDM5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.424	.003	36	view →
PDAC	DFS	Median	All	0.648	0.852	.009	11	view →
LSCC	OS	Tertile	II,III,IV	0.925	0.744	.010	6	view →
LUAD	DFS	Median	All	0.471	0.746	.013	4	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.789	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KDM5C–UCEC (DFS)

Open the UCEC breakdown →