KDM5C

Across TCGA patient cohorts, KDM5C protein abundance is significantly associated with the RNA expression of many other genes, with 17,570 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KDM5C-associated genes across cancer lineages are CDK16, FLI1, and POLA1. Each is linked with KDM5C in more than 5 cancer types. Because this analysis shows association rather than direction, both KDM5C-to-partner and partner-to-KDM5C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KDM5C versus CDK16 in BRCA, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5C→partner) and Y-score (partner→KDM5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDK16 →	+0.639	+0.352	<.001	<.001	3	6
BRCA	FLI1 →	-0.685	-0.281	<.001	.001	3	6
LSCC	POLA1 →	+0.578	+0.218	<.001	<.001	3	5
UCEC	CENPI →	+0.859	+0.239	<.001	<.001	3	5
UCEC	CDCA8 →	+0.846	+0.231	<.001	<.001	3	5
LSCC	TESPA1 →	-0.723	-0.331	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,570 associations by consensus.

KDM5C vs CDK16 — BRCA

Explore this scatter interactively →