KDM5C

Across TCGA patient cohorts, KDM5C mutation is significantly associated with the RNA expression of many other genes, with 6,077 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM5C-associated genes across cancer lineages are TMEM263, SHMT2, and DIABLO. Each is linked with KDM5C in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM5C-to-partner and partner-to-KDM5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM263 grouped by KDM5C-low versus KDM5C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5C→partner) and Y-score (partner→KDM5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM263 →	+0.677	+3.820	.001	<.001	3	3
LUAD	SHMT2 →	+0.546	+2.620	.007	.006	3	3
UCEC	DIABLO →	+0.329	+2.343	<.001	<.001	3	3
UCEC	CDCA2 →	+0.614	+2.514	<.001	<.001	3	3
UCEC	PPP1CC →	+0.298	+1.429	.009	.001	3	3
UCEC	TTC24 →	+0.267	+1.597	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,077 associations by consensus.

TMEM263 by KDM5C expression — COAD

Explore this box plot interactively →