KDM5C

Across TCGA cell cohorts, KDM5C mutation is significantly associated with the RNA expression of many other genes, with 281 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM5C-associated genes across cancer lineages are OR5C1, OVCH2, and UBE2QL1. Each is linked with KDM5C in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM5C-to-partner and partner-to-KDM5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5C1 grouped by KDM5C-low versus KDM5C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5C→partner) and Y-score (partner→KDM5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR5C1 →	+0.037	+3.455	<.001	.002	3	2
BLOOD_Leukemia	OVCH2 →	+0.859	+3.079	<.001	.006	3	2
BLOOD_Leukemia	UBE2QL1 →	+0.159	+3.007	.003	.007	3	2
UPPER_AERODIGESTIVE_TRACT	SEL1L2 →	+0.060	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	CYLC1 →	+0.023	+5.357	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

OR5C1 by KDM5C expression — BLOOD_Leukemia

Explore this box plot interactively →