KDM5B

Across TCGA pan-cancer cohorts, KDM5B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of KDM5B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where KDM5B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KDM5B is over-expressed in tumor.

LSCC, LUAD, and CCRCC are the cancer types where KDM5B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM5B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+0.579	<.001	9	view →
LUAD	Male	II,III,IV	+0.302	<.001	9	view →
CCRCC	All	All	+0.588	<.001	5	view →
PDAC	All	III,IV	+0.425	.004	3	view →
HNSC	All	III,IV	+0.194	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

KDM5B–LSCC

Open the LSCC breakdown →