KDM5A

Across TCGA pan-cancer cohorts, KDM5A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KDM5A data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KDM5A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KDM5A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where KDM5A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.902	0.710	.010	21	view →
LUAD	DFS	Tertile	All	1.000	0.672	.004	9	view →
CCRCC	DFS	Quartile	III,IV	0.316	0.804	.020	5	view →
PDAC	DFS	Tertile	All	0.584	0.372	.022	4	view →
HNSC	DFS	Quartile	All	1.000	0.916	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KDM5A–LSCC (OS)

Open the LSCC breakdown →