KDM5A

Across TCGA patient cohorts, KDM5A mutation is significantly associated with the RNA expression of many other genes, with 4,444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM5A-associated genes across cancer lineages are C1QBP, LETM1, and MED31. Each is linked with KDM5A in more than 4 cancer types. Because this analysis shows association rather than direction, both KDM5A-to-partner and partner-to-KDM5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by KDM5A-low versus KDM5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5A→partner) and Y-score (partner→KDM5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1QBP →	+0.377	+1.797	.002	<.001	3	5
LUSC	LETM1 →	+0.447	+3.357	.004	.005	3	4
UCEC	MED31 →	+0.389	+2.184	<.001	<.001	3	4
UCEC	CKS2 →	+0.524	+1.963	<.001	<.001	3	4
UCEC	YARS2 →	+0.324	+1.354	.001	.001	3	4
COAD	ATP5F1A →	+0.514	+3.361	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,444 associations by consensus.

C1QBP by KDM5A expression — UCEC

Explore this box plot interactively →