KDM5A

Across TCGA cell cohorts, KDM5A mutation is significantly associated with the RNA expression of many other genes, with 1,319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM5A-associated genes across cancer lineages are OR4F15, DDHD1, and SMCHD1. Each is linked with KDM5A in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM5A-to-partner and partner-to-KDM5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F15 grouped by KDM5A-low versus KDM5A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM5A→partner) and Y-score (partner→KDM5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR4F15 →	+0.144	+4.217	<.001	.005	3	2
LARGE_INTESTINE	DDHD1 →	+0.722	+3.321	<.001	.002	3	2
LARGE_INTESTINE	SMCHD1 →	+0.819	+3.321	.001	.002	3	2
LARGE_INTESTINE	NISCH →	+0.531	+1.850	.009	.006	3	2
LARGE_INTESTINE	CCNP →	+0.936	+2.364	.004	<.001	3	2
LARGE_INTESTINE	DHX15 →	+0.480	+2.364	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,319 associations by consensus.

OR4F15 by KDM5A expression — URINARY_TRACT

Explore this box plot interactively →