KDM4F

Across TCGA pan-cancer cohorts, KDM4F RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated KDM4F data layer.

The strongest signal is observed in mesothelioma (MESO), where higher KDM4F RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KDM4F expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

MESO, DLBC, and CESC are the cancer types where KDM4F RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.077	0.580	<.001	72	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
CESC	OS	Tertile	IV	0.106	0.619	<.001	36	view →
KIRC	DFS	Tertile	All	0.504	0.809	.001	30	view →
READ	DFS	Tertile	IV	0.112	0.811	.008	27	view →
ESCA	OS	Tertile	All	0.464	0.902	.004	24	view →
SKCM	OS	Tertile	III,IV	0.471	0.744	.009	21	view →
BLCA	OS	Tertile	IV	0.248	0.602	.032	18	view →
LGG	OS	Tertile	All	0.506	0.843	<.001	18	view →
PAAD	OS	Tertile	All	0.837	0.363	.030	9	view →
SARC	DFS	Tertile	All	0.182	0.506	.009	9	view →
LUSC	DFS	Tertile	II,III,IV	0.757	0.366	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

KDM4F–MESO (OS)

Open the MESO breakdown →