Across TCGA patient cohorts, KDM4D mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4D-associated genes across cancer lineages are Notch1, N-Ras, and EGFR. Each is linked with KDM4D in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM4D-to-partner and partner-to-KDM4D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4D→partner) and Y-score (partner→KDM4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.161	+1.710	.001	.025	3	2
SKCM	N-Ras →	+0.162	+3.000	.022	.035	3	1
UCEC	EGFR →	-0.179	-1.847	.002	.008	3	1
UCEC	eIF4E →	+0.202	+2.247	.009	.001	3	1
UCEC	eIF4G →	+0.304	+3.321	.007	.009	3	1
UCEC	FoxM1 →	+0.267	+2.594	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

KDM4D survival (RNA) · tumor vs normal (RNA) · all KDM4D data types