KDM4C

Across TCGA patient cohorts, KDM4C mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4C-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with KDM4C in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM4C-to-partner and partner-to-KDM4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by KDM4C-low versus KDM4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4C→partner) and Y-score (partner→KDM4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.092	-1.234	.025	.038	3	3
UCEC	Caspase-7-cleavedD198 →	+0.599	+1.604	<.001	.002	3	3
LUAD	Cyclin-B1 →	+0.762	+3.000	.004	.036	3	2
BLCA	PAI-1 →	+0.701	+3.017	.048	.019	3	2
BLCA	TAZ →	+0.296	+2.820	<.001	.035	3	2
UCEC	JNK2 →	+0.223	+1.874	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

mTOR_pS2448 by KDM4C expression — UCEC

Explore this box plot interactively →