KDM4B

Across TCGA pan-cancer cohorts, KDM4B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KDM4B data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KDM4B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KDM4B expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where KDM4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.350	.002	34	view →
PDAC	OS	Tertile	All	0.291	0.555	.002	26	view →
HNSC	DFS	Tertile	All	1.000	0.917	.010	14	view →
LSCC	DFS	Quartile	II,III,IV	0.874	0.492	.009	11	view →
LUAD	OS	Quartile	All	0.562	0.887	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KDM4B–UCEC (DFS)

Open the UCEC breakdown →