KDM3B

Across TCGA pan-cancer cohorts, KDM3B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KDM3B data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KDM3B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KDM3B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where KDM3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.612	0.833	.012	10	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.514	.022	3	view →
GBM	DFS	Tertile	All	0.388	0.243	.037	3	view →
PDAC	OS	Median	III,IV	0.917	0.625	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KDM3B–HNSC (OS)

Open the HNSC breakdown →