KDM3B

Across TCGA patient cohorts, KDM3B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM3B-associated genes across cancer lineages are STAT3_pY705, ASNS, and Caspase-7-cleavedD198. Each is linked with KDM3B in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM3B-to-partner and partner-to-KDM3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by KDM3B-low versus KDM3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM3B→partner) and Y-score (partner→KDM3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.309	-1.678	<.001	<.001	3	3
SKCM	ASNS →	+0.495	+1.584	.001	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.247	+2.321	<.001	.033	2	3
UCEC	eIF4E →	+0.108	+1.222	.046	.003	3	2
UCEC	ERK2 →	+0.182	+1.494	<.001	.001	3	2
UCEC	HER2_pY1248 →	-0.142	-1.662	.038	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

STAT3_pY705 by KDM3B expression — UCEC

Explore this box plot interactively →