KDM3B

Across TCGA cell cohorts, KDM3B mutation is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM3B-associated genes across cancer lineages are TMEM95, HERPUD1, and MSH4. Each is linked with KDM3B in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM3B-to-partner and partner-to-KDM3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM95 grouped by KDM3B-low versus KDM3B-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM3B→partner) and Y-score (partner→KDM3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TMEM95 →	+0.028	+4.108	<.001	.005	3	2
LARGE_INTESTINE	HERPUD1 →	+0.806	+2.628	.001	.002	3	2
LARGE_INTESTINE	MSH4 →	+0.259	+2.531	<.001	.001	3	2
LUNG_SCLC	SMIM31 →	+0.897	+3.669	<.001	.008	3	2
OESOPHAGUS	SLC17A2 →	+0.006	+4.906	<.001	.006	3	1
KIDNEY	MAGEB16 →	+0.162	+4.491	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

TMEM95 by KDM3B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →