KDM1B

Across TCGA pan-cancer cohorts, KDM1B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KDM1B data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KDM1B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM1B expression acts as an unfavorable survival marker.

HNSC, BLCA, and COAD are the cancer types where KDM1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.366	0.697	.002	27	view →
BLCA	OS	Median	III,IV	0.153	0.684	.001	21	view →
COAD	OS	Median	All	0.164	0.617	.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	OS	Median	All	0.021	0.890	<.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KDM1B–HNSC (DFS)

Open the HNSC breakdown →