KDM1B

Across TCGA pan-cancer cohorts, KDM1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KDM1B data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KDM1B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDM1B expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where KDM1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.647	0.823	.009	25	view →
LSCC	DFS	Tertile	All	0.999	0.819	.006	22	view →
LUAD	DFS	Tertile	III,IV	0.901	0.474	.024	3	view →
CCRCC	DFS	Tertile	All	0.844	0.404	.025	2	view →
UCEC	DFS	Median	All	1.000	0.938	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KDM1B–PDAC (DFS)

Open the PDAC breakdown →