KDM1B

Across TCGA patient cohorts, KDM1B mutation is significantly associated with the RNA expression of many other genes, with 2,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM1B-associated genes across cancer lineages are PISRT1, FAM177A1, and DPH3. Each is linked with KDM1B in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM1B-to-partner and partner-to-KDM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PISRT1 grouped by KDM1B-low versus KDM1B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM1B→partner) and Y-score (partner→KDM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PISRT1 →	+0.074	+3.760	<.001	.004	3	2
UCEC	FAM177A1 →	+0.398	+2.110	<.001	<.001	3	2
UCEC	DPH3 →	+0.315	+2.524	.005	<.001	3	2
UCEC	MON1A →	+0.367	+2.332	<.001	<.001	3	2
UCEC	DOLPP1 →	+0.432	+1.868	<.001	<.001	3	2
UCEC	ARF4 →	+0.382	+1.617	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,358 associations by consensus.

PISRT1 by KDM1B expression — CESC

Explore this box plot interactively →