KDM1B

Across TCGA cell cohorts, KDM1B mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KDM1B-associated genes across cancer lineages are OR5AU1, SH3GL2, and L3MBTL4. Each is linked with KDM1B in more than 1 cancer types. Because this analysis shows association rather than direction, both KDM1B-to-partner and partner-to-KDM1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by KDM1B-low versus KDM1B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM1B→partner) and Y-score (partner→KDM1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5AU1 →	+0.032	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.602	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	L3MBTL4 →	+1.057	+3.478	<.001	.002	3	1
LARGE_INTESTINE	ETNPPL →	+0.160	+2.436	.008	.008	3	1
LARGE_INTESTINE	RPSA →	+0.660	+3.064	.002	.009	3	1
LARGE_INTESTINE	CCDC110 →	+0.996	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR5AU1 by KDM1B expression — SKIN

Explore this box plot interactively →