KDELR3

Across TCGA pan-cancer cohorts, KDELR3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KDELR3 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KDELR3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KDELR3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where KDELR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.522	1.000	.008	11	view →
UCEC	DFS	Median	All	0.986	0.872	.020	4	view →
PDAC	OS	Median	II,III,IV	0.592	0.382	.018	4	view →
HNSC	DFS	Median	IV	0.679	0.933	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KDELR3–LSCC (OS)

Open the LSCC breakdown →