KDELR2

Across TCGA pan-cancer cohorts, KDELR2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated KDELR2 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher KDELR2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KDELR2 expression acts as an unfavorable survival marker, although some lineages such as PRAD and READ show a favorable association.

UVM, HNSC, and MESO are the cancer types where KDELR2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.409	0.780	<.001	141	view →
HNSC	OS	Median	All	0.607	0.755	<.001	121	view →
MESO	OS	Median	All	0.253	0.501	<.001	107	view →
KIRP	OS	Tertile	III,IV	0.100	0.680	<.001	91	view →
BRCA	OS	Tertile	All	0.558	0.662	<.001	86	view →
BLCA	DFS	Quartile	All	0.146	0.559	<.001	82	view →
ACC	DFS	Median	All	0.291	0.619	<.001	65	view →
CESC	DFS	Median	All	0.652	0.826	<.001	58	view →
LGG	OS	Median	All	0.729	0.894	<.001	52	view →
PAAD	OS	Median	All	0.311	0.636	<.001	46	view →
KICH	DFS	Quartile	III,IV	0.231	1.000	.005	42	view →
STAD	DFS	Median	All	0.596	0.715	.005	38	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

KDELR2–UVM (DFS)

Open the UVM breakdown →